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http://hdl.handle.net/11154/1269
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Title: | Large-scale oscillation of structure-related DNA sequence features in human chromosome 21 |
Authors: | Li, WT Miramontes, P |
Issue Date: | 2006 |
Abstract: | Human chromosome 21 is the only chromosome in the human genome that exhibits oscillation of the (G+C) content of a cycle length of hundreds kilobases (kb) (500 kb near the right telomere). We aim at establishing the existence of a similar periodicity in structure-related sequence features in order to relate this (G+C)% oscillation to other biological phenomena. The following quantities are shown to oscillate with the same 500 kb periodicity in human chromosome 21: binding energy calculated by two sets of dinucleotide-based thermodynamic parameters, AA/TT and AAA/TTT bi- and tri-nucleotide density, 5(')-TA-3(') dinucleotide density, and signal for 10- or 11-base periodicity of AA/TT or AAA/TTT. These intrinsic quantities are related to structural features of the double helix of DNA molecules, such as base-pair binding, untwisting or unwinding, stiffness, and a putative tendency for nucleosome formation. |
URI: | http://hdl.handle.net/11154/1269 |
ISSN: | 1539-3755 |
Appears in Collections: | Matemáticas
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