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http://hdl.handle.net/11154/1470
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Title: | Synthesis, crystal structures and anticancer activity of the new chiral mono-and dinuclear palladium(II) complexes derived from (S)-(-)-(1-phenylethylimino)benzylphenylketone |
Authors: | Pelaez, MA Ramiirez, T Martiinez, M Sharma, P Gutierrez, R Alvarez, C |
Issue Date: | 2004 |
Abstract: | The enantiopure ketoimine of benzil - the (S)-(-)-(1-phenylethylimino)benzyl phenyl ketone (1) obtained under microwave irradiation in solvent-free conditions - reacts with Na-2[PdCl4] to give the new chiral mono- and dinuclear Pd-complexes 2 and 3, which have been partly characterized by IR, H-1 and C-13 NMR spectroscopies along with MS-FAB(+) spectrometry. The crystal and molecular structures of both complexes has been fully confirmed by single-crystal X-ray studies. On the other hand, investigations in vitro of 2 and 3 have displayed growth inhibition against different classes of cancer: leukemia (K-562 CML), colon cancer (HCT-15), cancer breast (MCF-7), central nervous system (U-251 Glio) and prostate cancer (PC-3) cell lines. |
URI: | http://hdl.handle.net/11154/1470 |
ISSN: | 0044-2313 |
Appears in Collections: | Ciencias
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