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http://hdl.handle.net/11154/1616
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Title: | Structure and cytotoxicity of new metabolites from the sponge Mycale cecilia |
Authors: | Ortega, MJ Zubia, E Salva, J Carballo, JL Sánchez, MC |
Issue Date: | 2004 |
Abstract: | The chemical study of the sponge Mycale cecilia has led to the isolation of 14 new pyrrole-containing metabolites. Mycalazals 3-13 are pyrrole-2-carbaldehydes possessing at C-5 hydrocarbon side chains of different length and/or number of unsaturations. Mycalenitriles 1-3 are 5-cyanoalkylpyrrole-2-carbaldehydes. The structures of the new compounds were established mainly by NMR and MS spectroscopic analysis. The location of the double bond in mycalazal-4, -8, and -11 was determined by MS analysis of the corresponding bis(methylthio) derivatives. Mycalazals have shown activity as growth inhibitors of several tumor cell lines, in particular the LNcaP cell line, being mycalazal-8 the most active metabolite. (C) 2004 Elsevier Ltd. All rights reserved. |
URI: | http://hdl.handle.net/11154/1616 |
ISSN: | 0040-4020 |
Appears in Collections: | Ciencias
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