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http://hdl.handle.net/11154/1712
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Title: | Rotavirus diarrhea severity is related to the VP4 type in Mexican children |
Authors: | Calva, JJ Gutierrez-Camacho, C Villa-Contreras, S Arias, CF Padilla-Noriega, L Guiscafre-Gallardo, H Guerrero, MD Contreras, JF Cedillo, R Herrera, I Puerto, FI Mota-Hernández, F López, S Muñoz, O |
Issue Date: | 2003 |
Abstract: | This report is of a community-based case control study to assess whether the severity of acute diarrhea by rotavirus (RV) in young children is associated with a particular VP7 (G) or VP4 (P) RV serotype. Five hundred twenty children younger than 2 years of age with diarrhea lasting less than 3 days were age and gender matched with 520 children with no diarrhea. The G and P serotypes were determined with specific monoclonal antibodies, and the VP4 serotype specificity in a subgroup was confirmed by genotyping. Infection with a G3 serotype led to a higher risk of diarrhea than infection with a G1 serotype. Infection with a G3-nontypeable-P serotype was associated with more severe gastroenteritis than infection with a G3 (or G1) PIA[8] serotype. A child with diarrhea-associated dehydration was almost five times more likely to be infected with a G3-nontypeable-P serotype than a child without dehydration (P < 0.001). Moreover, the two predominant mono-types within serotype PIA[8] had significantly different clinical manifestations. In this study, the severity of RV-associated diarrhea was related to different P serotypes rather than to G serotypes. The relationship between serotype and clinical outcomes seems to be complex and to vary among different geographic areas. |
URI: | http://hdl.handle.net/11154/1712 |
ISSN: | 0095-1137 |
Appears in Collections: | Ciencias
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