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Repositorio Atenea de la Facultad de Ciencias, UNAM >
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Artículos sobre cisticercosis y T. solium publicados por investigadores mexicanos >
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http://hdl.handle.net/11154/174331
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Title: | Antibody responses and epitope specificities to the Taenia solium cysticercosis vaccines TSOL18 and TSOL45-1A |
Authors: | Kyngdon, CT Gauci, CG González, AE Flisser, A Zoli, A Read, AJ Martinez-Ocana, J Strugnell, RA Lightowlers, MW |
Issue Date: | 2006 |
Publisher: | Parasite Immunology |
Citation: | Kyngdon, CT; Gauci, CG; González, AE; Flisser, A; Zoli, A; Read, AJ; Martinez-Ocana, J; Strugnell, RA; Lightowlers, MW. (2006). Antibody responses and epitope specificities to the Taenia solium cysticercosis vaccines TSOL18 and TSOL45-1A. Parasite Immunology, 28(5), 191-199. |
Abstract: | Taenia solium is a cestode parasite that causes cysticercosis in humans and pigs. This study examined the antibody responses in pigs immunized with the TSOL18 and TSOL45-1A recombinant vaccines against T. solium cysticercosis. Immunization with these proteins induced specific, complement-fixing antibodies against the recombinant antigens that are believed to be associated with vaccine-induced protection against T. solium infection. Sera from immunized pigs were used to define the linear B-cell epitopes of TSOL18 and TSOL45-1A. Prominent reactivity was revealed to one linear epitope on TSOL18 and two linear epitopes on TSOL45-1A. These, and oncosphere antigens from other taeniid cestodes, contain a protein sequence motif suggesting that they may show a tertiary structure similar to the fibronectin type III domain (FnIII). Comparison of the location of linear antigenic epitopes in TSOL18 and TSOL45-1A within the proposed FnIII structure to those within related cestode vaccine antigens reveals conservation in the positioning of the epitopes between oncosphere antigens from different taeniid species. |
URI: | http://hdl.handle.net/11154/99825 10.1111/j.1365-3024.2006.00820.x http://hdl.handle.net/11154/174331 |
ISSN: | 0141-9838 |
Appears in Collections: | Artículos sobre cisticercosis y T. solium publicados por investigadores mexicanos
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