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http://hdl.handle.net/11154/174375
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Title: | Immunidiagnosis of taeniasis by croproantigen detection |
Authors: | Allan, JC Avila , G Noval, JG Flisser, A Craig , PS |
Issue Date: | 1990 |
Publisher: | Parasitology |
Citation: | Allan, JC; Avila , G; Noval, JG; Flisser, A; Craig , PS. (1990). Immunidiagnosis of taeniasis by croproantigen detection. Parasitology, 101, 473-477. |
Abstract: | Immunodiagnostic tests for Taenia-specific faecal antigen based on polyclonal rabbit antisera against Taenia saginata or Taenia solium proglottid extracts in capture-type ELISA assays have been developed. Taenia-specific antigen was detected in detergent-solubilized faecal extracts from T. solium- and T. saginata-infected hosts. Coproantigen from T. solium-infected hamsters did not cross-react with faeces from rodents infected with Hymenolepis diminuta, H. citelli, H. microstoma, Necator americanus, Strongyloides ratti or Nematospiroides dubius and feaces from uninfected animals. When the T. saginata-capture ELISA was tested with faecal samples positive for T. solium antigen, no cross-reactions were obtained. However, faecal samples from humans infected with T. solium or T. saginata, including some with extremely low egg counts, were cross-reactive by either test. Nevertheless, considerably higher O.D. values were obtained with stool samples from Taenia patients compared to Hymenolepis nana-infected or uninfected individuals. Two individuals, infected with Taenia sp. and positive for coproantigens by ELISA, became antigen-negative 6 days after treatment with Niclosamide. The possibility of developing species-specific immunodiagnostic tests for human taeniasis through coproantigen detection is discussed. |
URI: | http://hdl.handle.net/11154/99919 http://hdl.handle.net/11154/174375 |
ISSN: | 0031-1820 |
Appears in Collections: | Artículos sobre cisticercosis y T. solium publicados por investigadores mexicanos
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