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http://hdl.handle.net/11154/2020
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Title: | Synthesis and cytotoxic evaluation of N-1,N-m-bis[(tetrahydrobenzo[a]acridin-12-yl)phenyl]alkanediamides and N-1,N-m-bis[(tetrahydrobenzo[c]acridin-7-yl)phenyl]-alkanediamides |
Authors: | Martínez, R Cogordan, JA Mancera, C Diaz, ML |
Issue Date: | 2000 |
Abstract: | The title compounds were synthesized in four steps from 5,5-dimethyl-1, 3-cyclohexanedione as starting material. These compounds were evaluated against 60 tumoral cell lines, whereas the N-I,N-m-bis[benzo[c]acridin-7-yl]phenyl] alkanediamides displaying significant cytotoxic activity, the corresponding N-I,N-m-bis[benzo[a]acridin-12-yl]phenyl]alkanediamides derivatives were found to be less cytotoxic. (C) 2000 Elsevier Science S.A. All rights reserved. |
URI: | http://hdl.handle.net/11154/2020 |
ISSN: | 0014-827X |
Appears in Collections: | Ciencias
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