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http://hdl.handle.net/11154/2042
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| Title: | Synthesis of enantiomerically pure 2-amino alcohols from amino acids mediated by sulfoxides |
| Authors: | Yuste, F
Ortiz, B
Carrasco, A
Peralta, M
Quintero, L
Walls, F
Ruano, JLG
Sánchez-Obregon, R |
| Issue Date: | 2000 |
| Abstract: | Enantiomerically pure (R-1,S-2)- and (S-1,S-2)-2-amino alcohols can be easily synthesized by stereodivergent reduction of alpha'-(N-Boc)amino beta-keto sulfoxides (easily synthesized from readily available N-Boc amino eater hydrochlorides) with DIBAH (clr 82-92%) and DIBAH/ZnBr2 (de 80%), followed by hydrogenolysis of the C-S bond of the resulting hydroxy sulfoxides and final hydrolysis of the N-Boc protecting group. (C) 2000 Elsevier Science Ltd. All rights reserved. |
| URI: | http://hdl.handle.net/11154/2042 |
| ISSN: | 0957-4166 |
| Appears in Collections: | Ciencias
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