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http://hdl.handle.net/11154/2067
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Title: | Surfactant Protein Genetic Marker Alleles Identify a Subgroup of Tuberculosis in a Mexican Population |
Authors: | Lin, HM Salazar, MA Guo, XX DiAngelo, S Montano, M Luo, JM Selman, M García, A FLoros, J Pardo-Cemo, Annie |
Issue Date: | 2000 |
Abstract: | Pulmonary surfactant and its components are essential for normal lung function and are involved in local host defense, Surfactant protein (SP)-A and SP-D bind to and modulate phagocytosis of Mycobacterium tuberculosis by macrophages. Frequency comparisons of SP marker alleles in tuberculosis patients and healthy control subjects (tuberculin-skin test positive or general population) were performed, Regression analyses of the tuberculosis and the tuberculin-skin test positive groups revealed, on the basis of odds ratios, tuberculosis susceptibility (DA11_C and GATA_3) and protective (AAGG_2) marker alleles, Similarly, between tuberculosis patients and general population control subjects, susceptibility 1A(3), 6A(4), and B1013_A and protective AAGG_1, and AAGG_7 marker alleles were observed, Moreover, interactions were seen between alleles 6A(2) and 1A(3) (P = .0064) and between 1A(3) and B1013_A (P = .036), The findings indicate a possible involvement of SP alleles in tuberculosis pathogenesis. |
URI: | http://hdl.handle.net/11154/2067 |
ISSN: | 221899 |
Appears in Collections: | Departamento de Biología Celular
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