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Title: | In vitro inhibition of 1,3-beta-glucan synthase by glycolipids from convolvulaceous species |
Authors: | Castelli, MV Cortes, JCG Escalante, AM Bah, M Pereda-Miranda, R Ribas, JC Zacchino, SA |
Issue Date: | 2002 |
Abstract: | Sixteen convolvulaceous glycolipids selected from the tricolorin (1-7) and orizabin (8-16) series, proved to be strong in vitro inhibitors of the enzyme that catalyzes the synthesis of 1,3-beta-D-glucan, a major polymer of fungal cell-walls. Results provide an insight into function of the specific structures of these complex macrocyclic lactones as inhibitors of the 1,3-beta-D-glucan synthase and open the possibility of using these compounds as starting points for the development of antifungal agents that act by inhibiting fungal cell-wall synthesis. |
URI: | http://hdl.handle.net/11154/2513 |
ISSN: | 0032-0943 |
Appears in Collections: | Ciencias
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