Cytotoxic isoflavans from Eysenhardtia polystachya

Abstract

Two new cytotoxic isoflavans, (3S)-7-hydroxy-2',3',4',5',8-pentamethox (1) and (3S)3',7-dihydroxy-2',4', 5', 8-tetramethoxyisoflavan (2), were isolated from the bark and trunks of Eysenhardtia polystachya (Leguminosae), together with the known constituents stigmasterol, isoduartin, cuneatin, 7-hydroxy-2',4',5'-trimethoxyisoflavone, and 3,4-dimethoxy-8,9-(methylenedioxy)pterocarpan. The structures of 1 and 2 were elucidated on the basis of spectroscopic methods. The antimicrobial, cytotoxic, and insecticidal potential of some of these compounds were evaluated. The isoflavans 1, 2, and isoduartin (2',7-dihydroxy-3',4',8-trimethoxyisoflavan) displayed moderate cytotoxic activity against KB cell lines.