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http://hdl.handle.net/11154/3522
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Title: | MODELING GENETIC EVOLUTION WITH COUPLED MAP LATTICES |
Authors: | COCHO, G GELOVER, A BULAJICH, R MartínezMEKLER, G |
Issue Date: | 1992 |
Abstract: | The evolution of genetic sequences, in particular the case of retro-virus as encountered in AIDS, is analyzed by means of a coupled Map lattice model. Mutations are introduced as coupling terms and several ecological constraints are considered. The resulting equations are of the reaction-diffusion type. The model establishes an evolution fitness criteria in terms of dynamical and structural properties at the molecular level. Under a global ecological constraint, the model dynamics generates quasi-species and presents an error threshold. Qualitative predictions regarding the AIDS vims RNA stability under mutations are corroborated experimentally. |
URI: | http://hdl.handle.net/11154/3522 |
ISSN: | 0035-001X |
Appears in Collections: | Física
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