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Title: | SERUM AND URINARY CERULOPLASMIN IN EXPERIMENTAL NEPHROTIC SYNDROME |
Authors: | MAINERO, A CRUZ, C PEDRAZACHAVERRI, J |
Issue Date: | 1992 |
Abstract: | The levels of ceruloplasmin (Cp) and total protein were measured in serum and urine from rats with experimental nephrotic syndrome (NS) for 20 days after a single injection of puromycin amino-nucleoside (PAN). Control values for Cp in serum and urine were: 0.23 +/- 0.01 mg/ml and 0.063 mg/day, and those for total protein were: 7.1 +/- 0.14 g/dl and 2.1 +/- 0.6 mg/day, respectively. It was found that: a) serum Cp decreased on day 6, remained low until day 10 (0.07 +/- 0.01 to 0.08 +/- 0.01 mg/ml), and returned to control levels on day 12 b) total serum protein decreased on day 4, reached the lowest value on day 6 (3.3 +/- 0.3 g/dl) and returned to control levels on day 16 c) Cp in urine increased on day 6, reached a peak value on day 8 (0.62 +/- 0.07 mg/day), then decreased but remained high on day 20 and d) total protein in urine increased on day 5, reached a peak value on day 10 (692 +/- 59 mg/day) and returned to control values on day 20. There was a close association between the levels of Cp and total protein in serum and urine. The decrease of circulating Cp indicates that a typical acute phase response does not occur in the PAN-nephrotic rats. The loss of Cp in the urine of the nephrotic rats may contribute to the decrease in the serum levels of this protein. |
URI: | http://hdl.handle.net/11154/3538 |
ISSN: | 0147-958X |
Appears in Collections: | Ciencias
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