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Repositorio Atenea de la Facultad de Ciencias, UNAM >
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Please use this identifier to cite or link to this item:
http://hdl.handle.net/11154/3615
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| Title: | GLOBAL MINIMUM ENERGY CONFORMATIONS OF THYROTROPIN-RELEASING-HORMONE ANALOGS BY SIMULATED ANNEALING .2. |
| Authors: | GARDUNOJuárez, R
PérezNERI, F |
| Issue Date: | 1991 |
| Abstract: | Lowest contormational energy structures of seventeen thyrotropin releasing hormone analogs have been studied by simulated annealing. A surprising conformational similarity was observed for the peptide backbone. The possible role of each substituent in its biological activity is inferred. A composite hydrogen-bonding environment is proposed for the TRH with respect to receptor binding. |
| URI: | http://hdl.handle.net/11154/3615 |
| ISSN: | 0739-1102 |
| Appears in Collections: | Ciencias
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