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Please use this identifier to cite or link to this item: http://hdl.handle.net/11154/903

Title: Effect of oxcarbazepine on sleep architecture
Authors: Ayala-Guerrero, F
Mexicano, G
Hernández, M
González, V
Issue Date: 2009
Abstract: The most common side effects following administration of antiepileptic drugs involve alterations in sleep architecture and varying degrees of daytime sleepiness. Oxcarbazepine is a drug that is approved as monotherapy for the treatment of partial seizures and generalized tonic-clonic seizures. However, there is no information about its effects on sleep pattern organization
therefore, the objective of this work was to analyze such effects. Animals (Wistar rats) exhibited three different behavioral and electrophysiological states of vigilance: wakefulness, slow wave sleep (SWS), and rapid eye movement (REM) sleep. Oral treatment with oxcarbazepine (100 mg /kg) produced an increment in total sleep time throughout the recording period. This increment involved both SWS and REM sleep. Mean duration of the REM sleep phase was not affected. In contrast, the frequency of this sleep phase increased significantly across the 10-hour period. REM sleep latency shortened significantly. Results obtained in this work indicate that oxcarbazepine's acute effects point to hypnotic properties. (C) 2009 Elsevier Inc. All rights reserved.
URI: http://hdl.handle.net/11154/903
ISSN: 1525-5050
Appears in Collections:Ciencias

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