Alfa-glucosidase-inhibiting activity of some Mexican plants used in the treatment of type 2 diabetes

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Show simple item record Becerra-Jimenez, J Cárdenas-Vázquez, R Andrade-Cetto, Adolfo 2011-01-22T10:27:03Z 2011-01-22T10:27:03Z 2008
dc.identifier.issn 3788741
dc.description.abstract Type 2 diabetes is an endocrine disease, which accounts for 9% of deaths worldwide. The aim of oral therapy is to reach normoglycemia to prevent later complications. Among glucose-lowering medications, a-glucosidase inhibitors delay the absorption of ingested carbohydrates, reducing the postprandial glucose and insulin peaks. In the present study, we tested the butanolic extracts of four Mexican plants with respect to their alpha-glucosidase inhibition activity, without excluding other possible mechanisms of action. The plants Cecropia obtusifolia Bertol., Equisetum myriochaetum Schlecht & Chain, Acosmium panamense (Benth.) Yacolev and Malmea depressa (Baill) R.E. Fries are used in traditional medicine to treat type 2 diabetes. In previous studies, we have demonstrated these plants' hypoglycemic activity and determined the phytochemical composition of their extracts. Our results in n-STZ diabetic rats loaded with maltose showed that Malmea and Acosmium extracts decreased plasma glucose significantly from 30 min on resembling the effect of acarbose. Cecropia extract produced the highest reduction of plasma glucose, and at 90 min, the glucose level was lower than the fasting level, which suggests another mechanism of action. Equisetum did not exert any effect. In vitro assays of alpha-glucosidase activity showed an IC50 of 14 mu g/ml for Cecropia, 21 mu g/ml for Malmea, and 109 mu g/ml for Acosmium, which were lower than that of acarbose (128 mu g/ml). Equisetum did not show any significant effect on this assay, either. These results contribute to understand the mechanism of action of these plants on glucose metabolism. (C) 2007 Elsevier Ireland Ltd. All rights reserved. en_US
dc.language.iso en en_US
dc.title Alfa-glucosidase-inhibiting activity of some Mexican plants used in the treatment of type 2 diabetes
dc.type Artículo de investigación en_US
dc.identifier.idprometeo 956
dc.identifier.doi 10.1016/j.jep.2007.10.031
dc.source.novolpages 116(1):27-32
dc.subject.wos Plant Sciences
dc.subject.wos Chemistry, Medicinal
dc.subject.wos Integrative & Complementary Medicine
dc.subject.wos Pharmacology & Pharmacy
dc.description.index WoS: SCI, SSCI o AHCI
dc.subject.keywords medicinal plants
dc.subject.keywords type 2 diabetes
dc.subject.keywords alpha-glucosidase inhibitors
dc.subject.keywords n-STZ diabetic rat
dc.relation.journal Journal of Ethnopharmacology
dc.description.Departamento Departamento de Biología Comparada

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