Cytotoxic dibromotyrosine-derived metabolites from the sponge Aplysina gerardogreeni

dc.contributor.author	Zubia, E
dc.contributor.author	Ortega, MJ
dc.contributor.author	Carballo, JL
dc.contributor.author	Hernández-Guerrero, CJ
dc.date.accessioned	2011-01-22T10:26:17Z
dc.date.available	2011-01-22T10:26:17Z
dc.date.issued	2007
dc.identifier.issn	0968-0896
dc.identifier.uri	http://hdl.handle.net/11154/1128
dc.description.abstract	The chemical study of the sponge Aplysina gerardogreeni collected at the Gulf of California has led to the isolation of four new dibromotyrosine-derived metabolites, aplysinones A-D, whose structures were determined by spectroscopic analysis and chemical methods. The new compounds and four semisynthetic analogues prepared in this study have shown cytotoxic activity against human tumor cell lines. (c) 2007 Elsevier Ltd. All rights reserved.	en_US
dc.language.iso	en	en_US
dc.title	Cytotoxic dibromotyrosine-derived metabolites from the sponge Aplysina gerardogreeni	en_US
dc.type	Article	en_US
dc.identifier.idprometeo	1141
dc.identifier.doi	10.1016/j.bmc.2007.05.014
dc.source.novolpages	15(15):5275-5282
dc.subject.wos	Biochemistry & Molecular Biology
dc.subject.wos	Chemistry, Medicinal
dc.subject.wos	Chemistry, Organic
dc.description.index	WoS: SCI, SSCI o AHCI
dc.subject.keywords	natural products
dc.subject.keywords	sponges
dc.subject.keywords	dibromotyrosine-derived metabolites
dc.subject.keywords	structure determination
dc.subject.keywords	cytotoxicity
dc.relation.journal	Bioorganic & Medicinal Chemistry