Abstract:
The rules defining the AspAsp domain of RNAdependent polymerases deduced by Argos (1988) were tested in a set of 53 putative reverse transcriptases (RTs) sequences. Since it was found that some of these rules are not followed by RTs coded by bacteria, group II introns, and nonLTR retrotransposons, we present here a more strict definition of the AspAsp domain.