dc.contributor.author |
Becerra Bracho, Arturo Carlos ll |
|
dc.contributor.author |
Delaye, L |
|
dc.contributor.author |
Lazcano Araujo Reyes, Antonio Eusebio |
|
dc.contributor.author |
Orgel, L |
|
dc.date.accessioned |
20130312T14:38:32Z |
|
dc.date.available |
20130312T14:38:32Z |
|
dc.date.issued |
2007 |
|
dc.identifier.citation |
Becerra, A., Delaye, L., Lazcano, A. and Orgel, L. 2007. Protein disulfide oxidoreductases and the evolution of thermophily: was the last common ancestor a heat-loving microbe?. Journal of Molecular Evolution. 65: 296-303 |
en_US |
dc.identifier.issn |
14321432 |
|
dc.identifier.uri |
http://hdl.handle.net/11154/140292 |
|
dc.description.abstract |
Protein disulfide oxidoreductases (PDOs) are redox enzymes that catalyze dithioldisulfide exchange reactions. Their sequences and structure reveal the presence of two thioredoxin fold units, each of which is endowed with a catalytic site CXXC motif. PDOs are the outcome of an ancient gene duplication event. They have been described in a number of thermophilic and hyperthermophilic species, where they play a critical role in the structural stabilization of intracellular proteins. PDOs are homologous to both the Nterminal domain of the bacterial alkyl hydroperoxide reductase (AhpF) and to the eukaryotic protein disulfide isomerase (PDI). Phylogenetic analysis of PDOs suggests that they first evolved in the crenarchaeota, spreading freom them into the Bacteria via the euryarchaeota. These results imply that the last common ancestor (LCA) of all extant living beings lacked a PDO and argue, albeit weakly, against a thermophilic LCA. |
en_US |
dc.language.iso |
en |
en_US |
dc.title |
Protein disulfide oxidoreductases and the evolution of thermophily: was the last common ancestor a heatloving microbe? |
|
dc.type |
Artículo de investigación |
en_US |
dc.identifier.idprometeo |
1070 |
|
dc.identifier.doi |
10.1007/s0023900790050 |
|
dc.source.novolpages |
65(3): 296-303 |
|
dc.subject.wos |
Biochemistry & Molecular Biology |
|
dc.subject.wos |
Evolutionary Biology |
|
dc.subject.wos |
Genetics & Heredity |
|
dc.description.index |
WoS: SCI, SSCI o AHCI |
|
dc.subject.keywords |
protein disulfide oxidoreductases |
|
dc.subject.keywords |
thermophily |
|
dc.subject.keywords |
last common ancestor |
|
dc.subject.keywords |
horizontal gene transfer |
|
dc.relation.journal |
Journal of Molecular Evolution |
|
dc.description.Departamento |
Departamento de Biología Evolutiva |
|
dc.relation.Instadscription |
Facultad de Ciencias, UNAM |
|