dc.contributor.author |
Sharma, P |
|
dc.contributor.author |
Rosas, N |
|
dc.contributor.author |
Cabrera, A |
|
dc.contributor.author |
Toscano, A |
|
dc.contributor.author |
Silva, MD |
|
dc.contributor.author |
Perez, D |
|
dc.contributor.author |
Velasco, L |
|
dc.contributor.author |
Perez, J |
|
dc.contributor.author |
Gutierez, R |
|
dc.date.accessioned |
2011-01-22T10:26:32Z |
|
dc.date.available |
2011-01-22T10:26:32Z |
|
dc.date.issued |
2005 |
|
dc.identifier.issn |
0022-328X |
|
dc.identifier.uri |
http://hdl.handle.net/11154/1439 |
|
dc.description.abstract |
A new tertiary stibine and bismuthine containing C-heterocyclic selenophene ring have been synthesized. Tris(2-selenophenyl)stibine (1) and tris(2-selenophenyl) bismuthine (2) and characterized by IR, MS, H-1, C-13, COSY, HETCOR NMR spectroscopy. Crystal structures of stibine and bismuthine have been determined. In an attempted synthesis of tris(2-selenophenyl) phosphine, an oxidative product tris(2-selenophenyl) phosphine oxide (3) was isolated under the experimental conditions used, whose X-ray crystal structure was also determined. To best of our knowledge C-heterocyclic selenophene-2-yl pnictogens are first of their kind, as not many examples are known even with other p-block metal/metalloids. The biological activity of compound (1) was determined. The compound (1) shows a significant selectivity (> 85%) for carcinogenic cell K and U growth inhibition. The toxicity of tris(selenophen-2-yl) stibine (1) on larvae of Artemia Salina was studied and the LC50 value was 589.6 mu M. (c) 2005 Elsevier B.V. All rights reserved. |
en_US |
dc.language.iso |
en |
en_US |
dc.title |
First synthesis and structural report on selenophen-2-yl containing pnictogens: Biological activities of tris(selenophen-2-yl)stibine |
en_US |
dc.type |
Article |
en_US |
dc.identifier.idprometeo |
1588 |
|
dc.identifier.doi |
10.1016/j.jorganchem.2005.03.047 |
|
dc.source.novolpages |
690(13):3286-3291 |
|
dc.subject.wos |
Chemistry, Inorganic & Nuclear |
|
dc.subject.wos |
Chemistry, Organic |
|
dc.description.index |
WoS: SCI, SSCI o AHCI |
|
dc.subject.keywords |
selenophene |
|
dc.subject.keywords |
heterocyclic stibine |
|
dc.subject.keywords |
bismuthine |
|
dc.subject.keywords |
Sb-Se intermolecular intractions |
|
dc.subject.keywords |
biological activity |
|
dc.relation.journal |
Journal of Organometallic Chemistry |
|