dc.contributor.author |
Pelaez, MA |
|
dc.contributor.author |
Ramiirez, T |
|
dc.contributor.author |
Martiinez, M |
|
dc.contributor.author |
Sharma, P |
|
dc.contributor.author |
Gutierrez, R |
|
dc.contributor.author |
Alvarez, C |
|
dc.date.accessioned |
2011-01-22T10:27:15Z |
|
dc.date.available |
2011-01-22T10:27:15Z |
|
dc.date.issued |
2004 |
|
dc.identifier.issn |
0044-2313 |
|
dc.identifier.uri |
http://hdl.handle.net/11154/1470 |
|
dc.description.abstract |
The enantiopure ketoimine of benzil - the (S)-(-)-(1-phenylethylimino)benzyl phenyl ketone (1) obtained under microwave irradiation in solvent-free conditions - reacts with Na-2[PdCl4] to give the new chiral mono- and dinuclear Pd-complexes 2 and 3, which have been partly characterized by IR, H-1 and C-13 NMR spectroscopies along with MS-FAB(+) spectrometry. The crystal and molecular structures of both complexes has been fully confirmed by single-crystal X-ray studies. On the other hand, investigations in vitro of 2 and 3 have displayed growth inhibition against different classes of cancer: leukemia (K-562 CML), colon cancer (HCT-15), cancer breast (MCF-7), central nervous system (U-251 Glio) and prostate cancer (PC-3) cell lines. |
en_US |
dc.language.iso |
en |
en_US |
dc.title |
Synthesis, crystal structures and anticancer activity of the new chiral mono-and dinuclear palladium(II) complexes derived from (S)-(-)-(1-phenylethylimino)benzylphenylketone |
en_US |
dc.type |
Article |
en_US |
dc.identifier.idprometeo |
1622 |
|
dc.identifier.doi |
10.1002/zaac.200400140 |
|
dc.source.novolpages |
630(10):1489-1494 |
|
dc.subject.wos |
Chemistry, Inorganic & Nuclear |
|
dc.description.index |
WoS: SCI, SSCI o AHCI |
|
dc.subject.keywords |
palladium |
|
dc.subject.keywords |
anticancer activity |
|
dc.subject.keywords |
chiral complexes |
|
dc.subject.keywords |
enantiopure alpha-ketoimines |
|
dc.relation.journal |
Zeitschrift Fur Anorganische Und Allgemeine Chemie |
|