dc.contributor.author |
Selman, M |
|
dc.contributor.author |
Pardo-Cemo, Annie |
|
dc.date.accessioned |
2011-01-22T10:26:36Z |
|
dc.date.available |
2011-01-22T10:26:36Z |
|
dc.date.issued |
2004 |
|
dc.identifier.issn |
11240490 |
|
dc.identifier.uri |
http://hdl.handle.net/11154/1540 |
|
dc.description.abstract |
Idiopathic pulmonary fibrosis is a complex disease of unknown etiology which produces a progressive and irreversible destruction of the alveolar-capillary units leading ultimately to death from respiratory failure. For a long time the pathogenesis of the disease was attributed to an unresolved chronic alveolitis. However, a growing body of evidence suggests that inflammation does not play a major role in this disease, and that the pivotal pathogenic mechanisms include epithelial cell microinjuries/activation, and fibroblast migration, proliferation, and differentiation in myofibroblasts fort-ning discrete foci in the injured areas. Active fibroblasts/myofibroblasts from these foci may in turn disturb alveolar re-epithelialization, by provoking basement membrane disruption and epithelial cell apoptosis finally resulting in exaggerated extracellular matrix accumulation. This aberrant repair process annihilates the lung architecture leading to the honeycomb remodeling. |
en_US |
dc.language.iso |
en |
en_US |
dc.title |
Idiopathic pulmonary fibrosis: misunderstandings between epithelial cells and fibroblasts? |
|
dc.type |
Artículo de investigación |
en_US |
dc.identifier.idprometeo |
1718 |
|
dc.source.novolpages |
21(3):165-172 |
|
dc.subject.wos |
Respiratory System |
|
dc.description.index |
WoS: SCI, SSCI o AHCI |
|
dc.subject.keywords |
epithelial cells |
|
dc.subject.keywords |
fibroblasts |
|
dc.subject.keywords |
myofibroblasts |
|
dc.subject.keywords |
stem cells |
|
dc.subject.keywords |
lung fibrosis |
|
dc.relation.journal |
Sarcoidosis Vasculitis and Diffuse Lung Diseases |
|
dc.description.Departamento |
Departamento de Biología Comparada |
|