S-allylcysteine prevents amyloid-beta peptide-induced oxidative stress in rat hippocampus and ameliorates learning deficits

DSpace/Manakin Repository

Show simple item record Perez-Severiano, F Cuevas-Martínez, EY Guevara, J Limon, D Maldonado, PD Medina-Campos, ON Pedraza-Chaverri, J Santamaria, A Salvatierra-Sánchez, R Rodríguez-Perez, M 2011-01-22T10:26:39Z 2011-01-22T10:26:39Z 2004
dc.identifier.issn 0014-2999
dc.description.abstract The effects of S-allylcysteine on oxidative damage and spatial learning and memory deficits produced by an intrahippocampal injection of amyloid-beta peptide 25-35 (Abeta(25-35)) in rats were investigated. The formation of reactive oxygen species, lipid peroxidation and the activities of the antioxidant enzymes superoxide dismutase and glutathione peroxidase were all measured in hippocampus 120 min after Abeta(25-35) injection (1 mul of 100 muM solution), while learning and memory skills were evaluated 2 and 35 days after the infusion of Abeta(25-35) to rats, respectively. Abeta(25-35) increased both reactive oxygen species and lipid peroxidation, whereas pretreatment with S-allylcysteine (300 mg/kg, i.p.) 30 min before peptide injection decreased both of these markers. In addition, Abeta(25-35)-induced incorrect learning responses were prevented in most of trials by S-allylcysteine. In contrast, enzyme activities were found unchanged in all groups tested. Findings of this work: (i) support the participation of reactive oxygen species in Abeta(25-35)-induced hippocampal toxicity and learning deficits en_US
dc.description.abstract and (ii) suggest that the protective effects of S-allylcysteine were related to its ability to scavenge reactive oxygen species. (C) 2004 Elsevier B.V. All rights reserved. en_US
dc.language.iso en en_US
dc.title S-allylcysteine prevents amyloid-beta peptide-induced oxidative stress in rat hippocampus and ameliorates learning deficits en_US
dc.type Article en_US
dc.identifier.idprometeo 1818
dc.identifier.doi 10.1016/j.ejphar.2004.03.001
dc.source.novolpages 489(3):197-202
dc.subject.wos Pharmacology & Pharmacy
dc.description.index WoS: SCI, SSCI o AHCI
dc.subject.keywords oxidative injury
dc.subject.keywords amyloid-beta peptide
dc.subject.keywords garlic compound
dc.subject.keywords antioxidant defense
dc.subject.keywords learning
dc.subject.keywords memory
dc.subject.keywords Alzheimer disease
dc.relation.journal European Journal of Pharmacology

Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search DSpace

Advanced Search


My Account