Structure and cytotoxicity of new metabolites from the sponge Mycale cecilia

dc.contributor.author	Ortega, MJ
dc.contributor.author	Zubia, E
dc.contributor.author	Salva, J
dc.contributor.author	Carballo, JL
dc.contributor.author	Sánchez, MC
dc.date.accessioned	2011-01-22T10:26:40Z
dc.date.available	2011-01-22T10:26:40Z
dc.date.issued	2004
dc.identifier.issn	0040-4020
dc.identifier.uri	http://hdl.handle.net/11154/1616
dc.description.abstract	The chemical study of the sponge Mycale cecilia has led to the isolation of 14 new pyrrole-containing metabolites. Mycalazals 3-13 are pyrrole-2-carbaldehydes possessing at C-5 hydrocarbon side chains of different length and/or number of unsaturations. Mycalenitriles 1-3 are 5-cyanoalkylpyrrole-2-carbaldehydes. The structures of the new compounds were established mainly by NMR and MS spectroscopic analysis. The location of the double bond in mycalazal-4, -8, and -11 was determined by MS analysis of the corresponding bis(methylthio) derivatives. Mycalazals have shown activity as growth inhibitors of several tumor cell lines, in particular the LNcaP cell line, being mycalazal-8 the most active metabolite. (C) 2004 Elsevier Ltd. All rights reserved.	en_US
dc.language.iso	en	en_US
dc.title	Structure and cytotoxicity of new metabolites from the sponge Mycale cecilia	en_US
dc.type	Article	en_US
dc.identifier.idprometeo	1840
dc.identifier.doi	10.1016/j.tet.2004.01.056
dc.source.novolpages	60(11):2517-2524
dc.subject.wos	Chemistry, Organic
dc.description.index	WoS: SCI, SSCI o AHCI
dc.subject.keywords	natural products
dc.subject.keywords	sponges
dc.subject.keywords	pyrroles
dc.subject.keywords	structure determination
dc.subject.keywords	cytotoxicity
dc.relation.journal	Tetrahedron