Hypargyrin A, a Hemiacetalic Germacrolide from Viguiera hypargyrea (Asteraceae). Biogenetic Implications and Biological Evaluation

dc.contributor.author	Arellano-Martínez, R
dc.contributor.author	Delgado, G
dc.date.accessioned	2010-12-17T16:13:27Z
dc.date.available	2010-12-17T16:13:27Z
dc.date.issued	2010
dc.identifier.issn	1870-249X
dc.identifier.uri	http://hdlhandlenet/123456789/43
dc.description.abstract	A new hemiacetalic germacrolide 6, named hypargyrin A, was isolated from the aerial parts of Viguiera hypargyrea, along with the known compounds (8R, 9R)-beta-caryophyllene epoxide, entkaur-16-en-19-oic acid (1), hispidulin (2), 8 beta-epoxyangeloyloxy-14-acetoxy-tithifolin (3), 8 beta-epoxyangeloyloxy-14-hydroxy-tithifolin (4) and budlein B (5). Spectroscopic analysis of 6 allowed the structural correction of a compound isolated from Blainvillea gayana. Budlein B (5) can be considered the biogenetic precursor of 6, and two pathways for its formation are proposed. Hypargyrin A (6) did not display significant anti-inflammatory activity against ear edema in mice induced by TPA, but showed cytotoxic activity against HeLa (IC50 35.1 mu M) and Hep-2 (39.2 mu M) human cells.	en_US
dc.language.iso	en	en_US
dc.title	Hypargyrin A, a Hemiacetalic Germacrolide from Viguiera hypargyrea (Asteraceae). Biogenetic Implications and Biological Evaluation	en_US
dc.type	Article	en_US
dc.identifier.idprometeo	91
dc.source.novolpages	54(2):117-121
dc.subject.wos	Chemistry, Multidisciplinary
dc.description.index	WoS: SCI, SSCI o AHCI
dc.subject.keywords	Asteraceae
dc.subject.keywords	Viguiera hypargyrea
dc.subject.keywords	sesquiterpene lactones
dc.subject.keywords	germacrolides
dc.subject.keywords	hypargyrin A
dc.subject.keywords	budlein B
dc.subject.keywords	biogenesis
dc.subject.keywords	anti-inflammatory activity
dc.subject.keywords	cytotoxic activity
dc.relation.journal	Journal of the Mexican Chemical Society