dc.contributor.author |
Calva, JJ |
|
dc.contributor.author |
Gutierrez-Camacho, C |
|
dc.contributor.author |
Villa-Contreras, S |
|
dc.contributor.author |
Arias, CF |
|
dc.contributor.author |
Padilla-Noriega, L |
|
dc.contributor.author |
Guiscafre-Gallardo, H |
|
dc.contributor.author |
Guerrero, MD |
|
dc.contributor.author |
Contreras, JF |
|
dc.contributor.author |
Cedillo, R |
|
dc.contributor.author |
Herrera, I |
|
dc.contributor.author |
Puerto, FI |
|
dc.contributor.author |
Mota-Hernández, F |
|
dc.contributor.author |
López, S |
|
dc.contributor.author |
Muñoz, O |
|
dc.date.accessioned |
2011-01-22T10:26:45Z |
|
dc.date.available |
2011-01-22T10:26:45Z |
|
dc.date.issued |
2003 |
|
dc.identifier.issn |
0095-1137 |
|
dc.identifier.uri |
http://hdl.handle.net/11154/1712 |
|
dc.description.abstract |
This report is of a community-based case control study to assess whether the severity of acute diarrhea by rotavirus (RV) in young children is associated with a particular VP7 (G) or VP4 (P) RV serotype. Five hundred twenty children younger than 2 years of age with diarrhea lasting less than 3 days were age and gender matched with 520 children with no diarrhea. The G and P serotypes were determined with specific monoclonal antibodies, and the VP4 serotype specificity in a subgroup was confirmed by genotyping. Infection with a G3 serotype led to a higher risk of diarrhea than infection with a G1 serotype. Infection with a G3-nontypeable-P serotype was associated with more severe gastroenteritis than infection with a G3 (or G1) PIA[8] serotype. A child with diarrhea-associated dehydration was almost five times more likely to be infected with a G3-nontypeable-P serotype than a child without dehydration (P < 0.001). Moreover, the two predominant mono-types within serotype PIA[8] had significantly different clinical manifestations. In this study, the severity of RV-associated diarrhea was related to different P serotypes rather than to G serotypes. The relationship between serotype and clinical outcomes seems to be complex and to vary among different geographic areas. |
en_US |
dc.language.iso |
en |
en_US |
dc.title |
Rotavirus diarrhea severity is related to the VP4 type in Mexican children |
en_US |
dc.type |
Article |
en_US |
dc.identifier.idprometeo |
1981 |
|
dc.identifier.doi |
10.1128/JCM.41.7.3158-3162.2003 |
|
dc.source.novolpages |
41(7):3158-3162 |
|
dc.subject.wos |
Microbiology |
|
dc.description.index |
WoS: SCI, SSCI o AHCI |
|
dc.relation.journal |
Journal of Clinical Microbiology |
|