dc.contributor.author |
Kyngdon, CT |
|
dc.contributor.author |
Gauci, CG |
|
dc.contributor.author |
González, AE |
|
dc.contributor.author |
Flisser, A |
|
dc.contributor.author |
Zoli, A |
|
dc.contributor.author |
Read, AJ |
|
dc.contributor.author |
Martinez-Ocana, J |
|
dc.contributor.author |
Strugnell, RA |
|
dc.contributor.author |
Lightowlers, MW |
|
dc.date.accessioned |
2011-12-07T12:19:15Z |
|
dc.date.accessioned |
2014-01-28T15:16:48Z |
|
dc.date.available |
2011-12-07T12:19:15Z |
|
dc.date.available |
2014-01-28T15:16:48Z |
|
dc.date.issued |
2006 |
|
dc.identifier.citation |
Kyngdon, CT; Gauci, CG; González, AE; Flisser, A; Zoli, A; Read, AJ; Martinez-Ocana, J; Strugnell, RA; Lightowlers, MW. (2006). Antibody responses and epitope specificities to the Taenia solium cysticercosis vaccines TSOL18 and TSOL45-1A. Parasite Immunology, 28(5), 191-199. |
|
dc.identifier.issn |
0141-9838 |
|
dc.identifier.uri |
http://hdl.handle.net/11154/99825 |
|
dc.identifier.uri |
10.1111/j.1365-3024.2006.00820.x |
|
dc.identifier.uri |
http://hdl.handle.net/11154/174331 |
|
dc.description.abstract |
Taenia solium is a cestode parasite that causes cysticercosis in humans and pigs. This study examined the antibody responses in pigs immunized with the TSOL18 and TSOL45-1A recombinant vaccines against T. solium cysticercosis. Immunization with these proteins induced specific, complement-fixing antibodies against the recombinant antigens that are believed to be associated with vaccine-induced protection against T. solium infection. Sera from immunized pigs were used to define the linear B-cell epitopes of TSOL18 and TSOL45-1A. Prominent reactivity was revealed to one linear epitope on TSOL18 and two linear epitopes on TSOL45-1A. These, and oncosphere antigens from other taeniid cestodes, contain a protein sequence motif suggesting that they may show a tertiary structure similar to the fibronectin type III domain (FnIII). Comparison of the location of linear antigenic epitopes in TSOL18 and TSOL45-1A within the proposed FnIII structure to those within related cestode vaccine antigens reveals conservation in the positioning of the epitopes between oncosphere antigens from different taeniid species. |
|
dc.language.iso |
en |
|
dc.publisher |
Parasite Immunology |
|
dc.subject.classification |
51 |
|
dc.title |
Antibody responses and epitope specificities to the Taenia solium cysticercosis vaccines TSOL18 and TSOL45-1A |
|
dc.type |
Article |
|
dc.relation.index |
WoS |
|