Taenia solium: current understanding of laboratory animal models of taeniosis

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Show simple item record Flisser, A. Avila , G. Maravilla, P. Mendlovic, F. Leon-Cabrera, S. Cruz-Rivera, M. Garza, A. Gomez, B. Aguilar, L. Teran, N. Velasco, S Benitez, M. Jimenez-González, D. E. 2011-12-07T13:50:24Z 2014-01-28T15:16:55Z 2011-12-07T13:50:24Z 2014-01-28T15:16:55Z 2010
dc.identifier.citation Flisser, A.; Avila , G.; Maravilla, P.; Mendlovic, F.; Leon-Cabrera, S.; Cruz-Rivera, M.; Garza, A.; Gomez, B.; Aguilar, L.; Teran, N.; Velasco, S.; Benitez, M.; Jimenez-González, D. E.T(2010). Taenia solium: current understanding of laboratory animal models of taeniosis. Parasitology , 137(3), 347-357.
dc.identifier.issn 0031-1820
dc.identifier.uri 10.1017/S0031182010000272
dc.description.abstract Neurocysticercosis is a public health problem in many developing countries and is the most frequent parasitic disease of the brain. The human tapeworm carrier is the main risk factor for acquiring neurocysticercosis. Since the parasite lodges only in the human intestine, experimental models of Taenia solium taeniosis have been explored. Macaques, pigs, clogs, cats and rabbits are unsuccessful hosts even in immunodepressed status. By contrast, rodents are adequate hosts since tapeworms with mature, pregravid and, in some cases, gravid proglottids develop after infection. In this review, information that has been generated with experimental models of taeniosis clue to T. solium is discussed. Initially, the use of the model for immunodiagnosis of human taeniosis and evaluation of intervention measures is summarized. Next, descriptions of tapeworms and comparison of hamsters, gerbils and other mammals as experimental models are discussed, as well as data on the humoral immune response, the inflammatory reaction and the production of cytokines associated to Th1 and Th2 responses in the intestinal mucosa. Finally, evaluation of protection induced against the development of tapeworms by recombinant T. solium calreticulin in hamsters is summarized and compared to other studies.
dc.language.iso en
dc.publisher Parasitology
dc.title Taenia solium: current understanding of laboratory animal models of taeniosis
dc.type Article
dc.relation.index WoS

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