Aging and Interstitial Lung Diseases: Unraveling an Old Forgotten Player in the Pathogenesis of Lung Fibrosis

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Show simple item record Selman, M Rojas, M Mora, AL Pardo-Cemo, Annie 2011-01-21T10:35:25Z 2011-01-21T10:35:25Z 2010
dc.identifier.issn 10693424
dc.identifier.uri http://hdlhandlenet/123456789/232
dc.description.abstract Aging is a natural process characterized by a progressive functional impairment and reduced capacity to respond adaptively to environmental stimuli. Aging is associated with increased susceptibility to a variety of chronic diseases, including type 2 diabetes mellitus, cancer, and neurological diseases. Lung pathologies are not the exception, and the prevalence of several interstitial lung diseases (ILDs), primarily idiopathic pulmonary fibrosis, has been found to increase considerably with age. Although our understanding of the biology of aging has advanced remarkably in the last 2 decades, the molecular mechanisms linking aging to ILD remain unclear. Immunosenescence, oxidative stress, abnormal shortening of telomeres, apoptosis, and epigenetic changes affecting gene expression have been proposed to contribute to the aging process, and aging-associated diseases. Here, we review the emerging concepts highlighting the putative aging-associated abnormalities involved in some human ILDs. en_US
dc.language.iso en en_US
dc.title Aging and Interstitial Lung Diseases: Unraveling an Old Forgotten Player in the Pathogenesis of Lung Fibrosis
dc.type Artículo de investigación en_US
dc.identifier.idprometeo 73
dc.identifier.doi 10.1055/s-0030-1265901
dc.source.novolpages 31(5):607-617
dc.subject.wos Critical Care Medicine
dc.subject.wos Respiratory System
dc.description.index WoS: SCI, SSCI o AHCI
dc.subject.keywords Idiopathic pulmonary fibrosis
dc.subject.keywords lung fibrosis
dc.subject.keywords interstitial lung disease
dc.subject.keywords aging
dc.relation.journal Seminars in Respiratory and Critical Care Medicine
dc.description.Departamento Departamento de Biología Comparada

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