Abstract:
The title compounds were synthesized in four steps from 5,5-dimethyl-1, 3-cyclohexanedione as starting material. These compounds were evaluated against 60 tumoral cell lines, whereas the N-I,N-m-bis[benzo[c]acridin-7-yl]phenyl] alkanediamides displaying significant cytotoxic activity, the corresponding N-I,N-m-bis[benzo[a]acridin-12-yl]phenyl]alkanediamides derivatives were found to be less cytotoxic. (C) 2000 Elsevier Science S.A. All rights reserved.