dc.contributor.author | Lin, HM | |
dc.contributor.author | Salazar, MA | |
dc.contributor.author | Guo, XX | |
dc.contributor.author | DiAngelo, S | |
dc.contributor.author | Montano, M | |
dc.contributor.author | Luo, JM | |
dc.contributor.author | Selman, M | |
dc.contributor.author | García, A | |
dc.contributor.author | FLoros, J | |
dc.contributor.author | Pardo-Cemo, Annie | |
dc.date.accessioned | 2011-01-22T10:27:29Z | |
dc.date.available | 2011-01-22T10:27:29Z | |
dc.date.issued | 2000 | |
dc.identifier.issn | 221899 | |
dc.identifier.uri | http://hdl.handle.net/11154/2067 | |
dc.description.abstract | Pulmonary surfactant and its components are essential for normal lung function and are involved in local host defense, Surfactant protein (SP)-A and SP-D bind to and modulate phagocytosis of Mycobacterium tuberculosis by macrophages. Frequency comparisons of SP marker alleles in tuberculosis patients and healthy control subjects (tuberculin-skin test positive or general population) were performed, Regression analyses of the tuberculosis and the tuberculin-skin test positive groups revealed, on the basis of odds ratios, tuberculosis susceptibility (DA11_C and GATA_3) and protective (AAGG_2) marker alleles, Similarly, between tuberculosis patients and general population control subjects, susceptibility 1A(3), 6A(4), and B1013_A and protective AAGG_1, and AAGG_7 marker alleles were observed, Moreover, interactions were seen between alleles 6A(2) and 1A(3) (P = .0064) and between 1A(3) and B1013_A (P = .036), The findings indicate a possible involvement of SP alleles in tuberculosis pathogenesis. | en_US |
dc.language.iso | en | en_US |
dc.title | Surfactant Protein Genetic Marker Alleles Identify a Subgroup of Tuberculosis in a Mexican Population | |
dc.type | Artículo de investigación | en_US |
dc.identifier.idprometeo | 2442 | |
dc.source.novolpages | 182(5):1473-1478 | |
dc.subject.wos | Immunology | |
dc.subject.wos | Infectious Diseases | |
dc.subject.wos | Microbiology | |
dc.description.index | WoS: SCI, SSCI o AHCI | |
dc.relation.journal | Journal of Infectious Diseases | |
dc.description.Departamento | Departamento de Biología Comparada |