Phosphatase-triggered guest release from a cyclodextrin complex

dc.contributor.author	Cho, A
dc.contributor.author	Lara, KLO
dc.contributor.author	Yatsimirsky, AK
dc.contributor.author	Eliseev, AV
dc.date.accessioned	2011-01-22T10:27:34Z
dc.date.available	2011-01-22T10:27:34Z
dc.date.issued	2000
dc.identifier.issn	1523-7060
dc.identifier.uri	http://hdl.handle.net/11154/2079
dc.description.abstract	[GRAPHICS] A synthetic supramolecular system is described that models the effect of phosphoryl transfer in molecular recognition. beta-Cyclodextrin-6A-phosphate (pCD), which is shown to be a substrate of alkaline phosphatase, binds cationic aromatic guests, including anticancer agents, up to 100-fold better than native beta-CD. The above observations demonstrate that pCD is capable of releasing the guests from its cavity upon hydrolysis with the phosphatase, as also confirmed by monitoring the hydrolysis in the presence of a guest.	en_US
dc.language.iso	en	en_US
dc.title	Phosphatase-triggered guest release from a cyclodextrin complex	en_US
dc.type	Article	en_US
dc.identifier.idprometeo	2509
dc.source.novolpages	2(12):1741-1743
dc.subject.wos	Chemistry, Organic
dc.description.index	WoS: SCI, SSCI o AHCI
dc.relation.journal	Organic Letters