dc.contributor.author | Selman, M | |
dc.contributor.author | Pardo-Cemo, Annie | |
dc.date.accessioned | 2011-01-22T10:27:45Z | |
dc.date.available | 2011-01-22T10:27:45Z | |
dc.date.issued | 1999 | |
dc.identifier.issn | 2133911 | |
dc.identifier.uri | http://hdl.handle.net/11154/2689 | |
dc.description.abstract | Pulmonary emphysema refers to a lung disorder characterized by a diffuse destruction of the alveolar walls resulting in enlargement of the distal airspaces. The disease is usually a chronic, progressive, and disabling disorder. The concept of proteinase/antiproteinase imbalance evolved from the identification of patients with alpha 1-antytripsin deficiency, and from the development of experimental emphysematous lesions using different enzymes. For a long time, this concept was seen as an elastase/antielastase imbalance, with the consequent degradation of elastin. Recent evidence, however, suggests that an intricate process of pulmonary remodeling occurs during the development of emphysema, where a complex network of serine proteases and metalloproteinases capable of degrading different extracellular matrix molecules, primarily, but not exclusively fibrillar collagens and elastin, are implicated in the pathogenesis of this disease. | en_US |
dc.language.iso | en | en_US |
dc.title | Proteinase-antiproteinase imbalance in the pathogenesis of emphysema: The role of metalloproteinases in lung damage | |
dc.type | Artículo de investigación | en_US |
dc.identifier.idprometeo | 2736 | |
dc.source.novolpages | 14(1):227-233 | |
dc.subject.wos | Cell Biology | |
dc.subject.wos | Pathology | |
dc.description.index | WoS: SCI, SSCI o AHCI | |
dc.subject.keywords | pulmonary emphysema | |
dc.subject.keywords | metalloproteinases | |
dc.subject.keywords | elastase | |
dc.subject.keywords | collagenase | |
dc.relation.journal | Histology and Histopathology | |
dc.description.Departamento | Departamento de Biología Comparada |
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