Abstract:
An alkaloid d-tubocurarine in aqueous solution binds 8-anilino-1-naphthalenesulfonate and anions of substituted benzoic, aliphatic dicarboxylic, and N-acetyl-alpha-amino acids. The binding constants vary from ca. 50 to 3300 M(-1) depending on the anion structure, charge and hydrophobicity. The binding of N-acetyl-alpha-amino acids is enantiospecific.