dc.contributor.author |
Aranda, JH |
|
dc.contributor.author |
Rodríguez-Arnaiz, R |
|
dc.date.accessioned |
2011-01-22T10:28:34Z |
|
dc.date.available |
2011-01-22T10:28:34Z |
|
dc.date.issued |
1994 |
|
dc.identifier.issn |
8936692 |
|
dc.identifier.uri |
http://hdl.handle.net/11154/3083 |
|
dc.description.abstract |
Aromatic amines represent a category of classical environmental hazards which require biotransformation in order to exert their mutagenic and carcinogenic effects. The mutagenic activity of several aromatic amines was tested by means of the w/w(+) somatic assay of Drosophila melanogaster employing a wild-type strain Leiden Standard (LS) and an insecticide-resistant stock Hikone-R (HK-R). Four monocyclic-ortho-anisidine (O-AN), ortho-toluidine (O-TO), 2,4-diaminoanisole (2,4-DAA) and 4-nitro-o-phenylenediamine (4-N-o-PDA), and one bicyclic- 4,4'-oxidianiline (4,4'-ODA) aromatic amines were tested by chronic exposure. Two separate experiments were run, and concurrent controls were treated with the solvent mixture. Results show that the ortho-anilines (O-AN and O-TO) were active in the assay, while the diamines containing a methoxy (2,4-DAA) or a nitro group (4-N-o-PDA) were inactive. The bicyclic aromatic amine, 4,4'-ODA, was the most potent. The genotoxic responsiveness of both strains was very similar. (C) 1994 Wiley-Liss, Inc. |
en_US |
dc.language.iso |
en |
en_US |
dc.title |
Activity of Aromatic Amines in the Eye: w/w+ Somatic Assay of Drosophila melanogaster |
|
dc.title |
|
Inglés |
dc.type |
Artículo de investigación |
en_US |
dc.identifier.idprometeo |
3255 |
|
dc.source.novolpages |
24(1):75-79 |
|
dc.subject.wos |
Environmental Sciences |
|
dc.subject.wos |
Genetics & Heredity |
|
dc.subject.wos |
Toxicology |
|
dc.description.index |
WoS: SCI, SSCI o AHCI |
|
dc.subject.keywords |
Aromatic Amines |
|
dc.subject.keywords |
Drosophila w/w+ Somatic Assay |
|
dc.subject.keywords |
Wild type (LS) |
|
dc.subject.keywords |
Insecticide Resistant (HK-R) Strains |
|
dc.subject.keywords |
Mutation |
|
dc.relation.journal |
Environmental and Molecular Mutagenesis |
|
dc.description.Departamento |
Departamento de Biología Comparada |
|