dc.contributor.author |
Selman, M |
|
dc.contributor.author |
Pardo-Cemo, Annie |
|
dc.date.accessioned |
2011-01-22T10:26:36Z |
|
dc.date.available |
2011-01-22T10:26:36Z |
|
dc.date.issued |
2005 |
|
dc.identifier.issn |
13572725 |
|
dc.identifier.uri |
http://hdl.handle.net/11154/3219 |
|
dc.description.abstract |
The matrix metalloproteinases (MMPs) area family of zinc-containing endopeptidases that play a key role in both physiological and pathological tissue remodeling. Human fibroblast collagenase (MMP-1) was the first vertebrate collagenase purified as a protein and cloned as a cDNA, and is considered the prototype for all the interstitial collagenases. It is synthesized as a zymogen where N-terminal residues are removed by proteolysis and shares with other MMPs a catalytic domain and a carboxy terminal domain with sequence similarity to hemopexin. Importantly, MMP-1 should be considered a multifunctional molecule since it participates not only in the turnover of collagen fibrils in the extracellular space but also in the cleavage of a number of non-matrix substrates and cell surface molecules suggesting a role in the regulation of cellular behaviour. Furthermore, an extensive body of evidence indicates that MMP-1 plays an important role in diverse physiologic processes such as development, tissue morphogenesis, and wound repair. Likewise, it seems to be implicated in a variety of human diseases including cancer, rheumatoid arthritis, pulmonary emphysema and fibrotic disorders, suggesting that its inhibition or stimulation may open therapeutic avenues. (C) 2004 Elsevier Ltd. All rights reserved. |
en_US |
dc.language.iso |
en |
en_US |
dc.title |
MMP-1: the elder of the family |
|
dc.type |
Artículo de investigación |
en_US |
dc.identifier.idprometeo |
1720 |
|
dc.identifier.doi |
10.1016/j.biocel.2004.06.017 |
|
dc.source.novolpages |
37(2):283-288 |
|
dc.subject.wos |
Biochemistry & Molecular Biology |
|
dc.subject.wos |
Cell Biology |
|
dc.description.index |
WoS: SCI, SSCI o AHCI |
|
dc.subject.keywords |
fibrosis |
|
dc.subject.keywords |
collagenase |
|
dc.subject.keywords |
matrix metalloproteinases |
|
dc.subject.keywords |
cancer |
|
dc.relation.journal |
International Journal of Biochemistry & Cell Biology |
|
dc.description.Departamento |
Departamento de Biología Comparada |
|