Abstract:
Oximation of ortho-substituted phenylbenz[a]acridinones using hydroxylamine hydrochloride, sodium hydroxide and ethanol as the solvent gave always the benzoquinacridine N-oxide 2. Oximation of parasubstituted phenylbenz[a]acridinones, however, gave only the corresponding oximes. The structure of all products was corroborated by ir, H-1 and C-13-nmr and mass spectral data. Theoretical calculations support the experimental findings.