dc.contributor.author |
MAINERO, A |
|
dc.contributor.author |
CRUZ, C |
|
dc.contributor.author |
PEDRAZACHAVERRI, J |
|
dc.date.accessioned |
2011-01-22T10:28:45Z |
|
dc.date.available |
2011-01-22T10:28:45Z |
|
dc.date.issued |
1992 |
|
dc.identifier.issn |
0147-958X |
|
dc.identifier.uri |
http://hdl.handle.net/11154/3538 |
|
dc.description.abstract |
The levels of ceruloplasmin (Cp) and total protein were measured in serum and urine from rats with experimental nephrotic syndrome (NS) for 20 days after a single injection of puromycin amino-nucleoside (PAN). Control values for Cp in serum and urine were: 0.23 +/- 0.01 mg/ml and 0.063 mg/day, and those for total protein were: 7.1 +/- 0.14 g/dl and 2.1 +/- 0.6 mg/day, respectively. It was found that: a) serum Cp decreased on day 6, remained low until day 10 (0.07 +/- 0.01 to 0.08 +/- 0.01 mg/ml), and returned to control levels on day 12 |
en_US |
dc.description.abstract |
b) total serum protein decreased on day 4, reached the lowest value on day 6 (3.3 +/- 0.3 g/dl) and returned to control levels on day 16 |
en_US |
dc.description.abstract |
c) Cp in urine increased on day 6, reached a peak value on day 8 (0.62 +/- 0.07 mg/day), then decreased but remained high on day 20 |
en_US |
dc.description.abstract |
and d) total protein in urine increased on day 5, reached a peak value on day 10 (692 +/- 59 mg/day) and returned to control values on day 20. There was a close association between the levels of Cp and total protein in serum and urine. The decrease of circulating Cp indicates that a typical acute phase response does not occur in the PAN-nephrotic rats. The loss of Cp in the urine of the nephrotic rats may contribute to the decrease in the serum levels of this protein. |
en_US |
dc.language.iso |
en |
en_US |
dc.title |
SERUM AND URINARY CERULOPLASMIN IN EXPERIMENTAL NEPHROTIC SYNDROME |
en_US |
dc.type |
Article |
en_US |
dc.identifier.idprometeo |
3409 |
|
dc.source.novolpages |
15(4):295-300 |
|
dc.subject.wos |
Medicine, Research & Experimental |
|
dc.description.index |
WoS: SCI, SSCI o AHCI |
|
dc.subject.keywords |
CERULOPLASMIN |
|
dc.subject.keywords |
NEPHROTIC SYNDROME |
|
dc.subject.keywords |
PUROMYCIN AMINONUCLEOSIDE |
|
dc.subject.keywords |
PROTEINURIA |
|
dc.relation.journal |
Clinical and Investigative Medicine-Medecine Clinique Et Experimentale |
|