MICA polymorphisms and decreased expression of the MICA receptor NKG2D contribute to idiopathic pulmonary fibrosis susceptibility

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Show simple item record Aquino-Galvez, A Camarena, A Falfan-Valencia, R Ruiz, V Montano, M Barrera, L Sada-Ovalle, I Ramirez, R Granados, J Selman, M Perez-Rodríguez, M Pardo-Cemo, Annie 2011-01-22T10:25:53Z 2011-01-22T10:25:53Z 2009
dc.identifier.issn 3406717
dc.description.abstract pC = 0.01). Strong immunoreactive MICA staining was localized in alveolar epithelial cells and fibroblasts from IPF lungs while control lungs were negative. Soluble MICA was detected in 35% of IPF patients compared with 12% of control subjects (P = 0.0007). The expression of NKG2D was significantly decreased in gamma delta T cells and natural killer cells obtained from IPF lungs. These findings indicate that MICA polymorphisms and abnormal expression of the MICA receptor NKG2D might contribute to IPF susceptibility. en_US
dc.description.abstract Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal lung disorder of unknown etiology. IPF is likely the result of complex interrelationships between environmental and host factors, although the genetic risk factors are presently uncertain. Because we have found that some MHC polymorphisms confer susceptibility to IPF, in the present study we aimed to evaluate the role of the MHC class I chain-related gene A (MICA) in the risk of developing the disease. MICA molecular typing was done by reference strand mediated conformation analysis in a cohort of 80 IPF patients and 201 controls. In addition, the lung cellular source of the protein was examined by immunohistochemistry, the expression of the MICA receptor NKG2D in lung cells by flow cytometry and soluble MICA by ELISA. A significant increase of MICA001 was observed in the IPF cohort (OR = 2.91, 95% CI = 1.04-8.25 en_US
dc.description.abstract pC = 0.03). Likewise, the frequency of the MICA001/00201 genotype was significantly increased in patients with IPF compared with the healthy controls (OR = 4.72, 95% CI = 1.15-22.51 en_US
dc.language.iso en en_US
dc.title MICA polymorphisms and decreased expression of the MICA receptor NKG2D contribute to idiopathic pulmonary fibrosis susceptibility
dc.type Artículo de investigación en_US
dc.identifier.idprometeo 545
dc.identifier.doi 10.1007/s00439-009-0666-1
dc.source.novolpages 125(40669):639-648
dc.subject.wos Genetics & Heredity
dc.description.index WoS: SCI, SSCI o AHCI
dc.relation.journal Human Genetics
dc.description.Departamento Departamento de Biología Comparada

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